Are Phosphatidic Acids Ubiquitous in Mammalian Tissues or Overemphasized in Mass Spectrometry Imaging Applications?

The cover feature image shows a cartoon representation of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI), which can produce in-source fragmentation lipids and cause artificial annotations from biological samples, particularly for phosphatidic acids. Whether these are endogenous or may be assessed by comparison with nanospray desorption electrospray ionization (nano-DESI-MSI). More information found in the Research Article Christopher Anderton co-workers.